MYB Antikörper (AA 506-534)

Produktnummer ABIN3029530

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MYB in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für MYB Antikörper (AA 506-534) (ABIN3029530)

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MYB Antikörper

Bindungsspezifität: AA 506-534

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 506-534 from the human protein was used as the immunogen for this Myb antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Myb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Myb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Andere Bezeichnung: Myb

Hintergrund: Myb is a transcriptional activator, DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.

UniProt: P10242

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process