NLRP4 Antikörper (AA 121-149)

Produktnummer ABIN3032022

Produktdetails anti-NLRP4 Antikörper

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Bindungsspezifität: AA 121-149

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP4 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 121-149 from the human protein was used as the immunogen for this NLRP4 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the NLRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the NLRP4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Andere Bezeichnung: NLRP4 (NLRP4 Produkte)

Synonyme: CLR19.5 antikoerper, CT58 antikoerper, NALP4 antikoerper, PAN2 antikoerper, PYPAF4 antikoerper, RNH2 antikoerper, Nalp4 antikoerper, Nlrp4e antikoerper, RGD1563529 antikoerper, NLR family pyrin domain containing 4 antikoerper, NLR family, pyrin domain containing 4 antikoerper, NLRP4 antikoerper, Nlrp4 antikoerper

Hintergrund: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).

UniProt: Q96MN2

Pathways: Inflammasome