GTPase NRas Antikörper (AA 72-101)
Kurzübersicht für GTPase NRas Antikörper (AA 72-101) (ABIN3031130)
Target
Alle GTPase NRas (NRAS) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 72-101
-
Kreuzreaktivität (Details)
- Expected species reactivity: Chicken, Mouse, Pig, Rat
-
Aufreinigung
- Purified
-
Immunogen
- A portion of amino acids 72-101 from the human protein was used as the immunogen for this NRAS antibody.
-
Isotyp
- Ig Fraction
-
-
-
-
Applikationshinweise
- Titration of the NRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Aliquot the NRAS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- GTPase NRas (NRAS)
-
Andere Bezeichnung
- NRAS
-
Hintergrund
- NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
-
UniProt
- P01111
-
Pathways
- p53 Signalweg, MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
Target
-