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SQSTM1 Antikörper (AA 317-346)

Name: SQSTM1 Antikörper (AA 317-346)
SKU: ABIN3031543
Price: 628.5 EUR
Availability: InStock

SQSTM1 Reaktivität: Human, Green Monkey WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of p62 antibody pre-incubated without (Lane 1) and with (2) blocking peptide in MCF-7 lysate (SQSTM1 Antikörper (AA 317-346))

Fluorescent image of U251 cells stained with p62 antibody at 1:200. (SQSTM1 Antikörper (AA 317-346))

IHC analysis of FFPE human hepatocarcinoma tissue stained with the p62 antibody (SQSTM1 Antikörper (AA 317-346))

IHC

Immunofluorescence staining of p62 antibody on Methanol-fixed and PFA fixed HeLa cells. (SQSTM1 Antikörper (AA 317-346))

Western blot testing of p62 antibody at 1:500 dilution + HeLa lysate; Predicted band size : 47~62 kDa. (SQSTM1 Antikörper (AA 317-346))

Western blot testing of p62 antibody at 1:500 dilution + HeLa lysate (SQSTM1 Antikörper (AA 317-346))

Western blot analysis of p6 antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SQSTM1/p62 gene (2). (SQSTM1 Antikörper (AA 317-346))

IHC

10 Abbildungen

Produktnummer ABIN3031543

Datenblatt (PDF)

Target Alle SQSTM1 Antikörper anzeigen

SQSTM1 (Sequestosome 1 (SQSTM1))
Bindungsspezifität
19

17

15

13

8

7

7

7

6

6

6

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 317-346
Reaktivität
149

65

61

18

4

4

4

4

3

2

2

2

1

1

1
Human, Green Monkey
Wirt
125

22

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
127

22
Polyklonal
Konjugat
70

11

10

7

7

6

4

4

4

4

4

4

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser SQSTM1 Antikörper ist unkonjugiert
Applikation
100

55

39

36

21

16

16

15

14

13

9

5

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität (Details)

Expected species reactivity: Mouse, Rat

Aufreinigung

Antigen affinity purified

Immunogen

A portion of amino acids 317-346 from the human protein was used as the immunogen for this p62 antibody.

Isotyp

Ig Fraction

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Applikationshinweise

Titration of the p62 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:50-1:100

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Aliquot the p62 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target

SQSTM1 (Sequestosome 1 (SQSTM1))

Andere Bezeichnung

p62 (SQSTM1) (SQSTM1 Produkte)

Synonyme

SQSTM1 antikoerper, sqstm1 antikoerper, MGC79491 antikoerper, A170 antikoerper, OSIL antikoerper, PDB3 antikoerper, ZIP3 antikoerper, p60 antikoerper, p62 antikoerper, p62B antikoerper, OSF-6 antikoerper, Osi antikoerper, STAP antikoerper, ZIP antikoerper, sb:cb621 antikoerper, zgc:85784 antikoerper, sequestosome 1 antikoerper, sequestosome 1 L homeolog antikoerper, SQSTM1 antikoerper, sqstm1 antikoerper, Sqstm1 antikoerper, sqstm1.L antikoerper

Hintergrund

SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.

UniProt

Q13501

Pathways

NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie