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LRRK2 Antikörper (AA 930-961)

LRRK2 Reaktivität: Human, Maus WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031610
  • Target Alle LRRK2 Antikörper anzeigen
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Bindungsspezifität
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 930-961
    Reaktivität
    Human, Maus
    Wirt
    • 8
    • 3
    Kaninchen
    Klonalität
    • 8
    • 3
    Polyklonal
    Konjugat
    • 11
    Dieser LRRK2 Antikörper ist unkonjugiert
    Applikation
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 930-961 from the human protein was used as the immunogen for this PARK8 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product LRRK2 Primärantikörper
  • Applikationshinweise
    Titration of the PARK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the PARK8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Andere Bezeichnung
    PARK8 (LRRK2 Produkte)
    Synonyme
    LRRK2 antikoerper, AURA17 antikoerper, DARDARIN antikoerper, PARK8 antikoerper, RIPK7 antikoerper, ROCO2 antikoerper, 4921513O20Rik antikoerper, 9330188B09Rik antikoerper, AW561911 antikoerper, D630001M17Rik antikoerper, Gm927 antikoerper, cI-46 antikoerper, leucine-rich repeat kinase 2 antikoerper, leucine rich repeat kinase 2 antikoerper, lrrk2 antikoerper, LRRK2 antikoerper, Lrrk2 antikoerper
    Hintergrund
    Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2/PARK8, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. PARK8 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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