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PERK Antikörper (AA 148-175)

EIF2AK3 Reaktivität: Human ELISA, WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3030887
  • Target Alle PERK (EIF2AK3) Antikörper anzeigen
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    Bindungsspezifität
    • 16
    • 16
    • 11
    • 9
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 148-175
    Reaktivität
    • 111
    • 72
    • 71
    • 16
    • 16
    Human
    Wirt
    • 103
    • 5
    • 3
    • 1
    Kaninchen
    Klonalität
    • 107
    • 5
    Polyklonal
    Konjugat
    • 35
    • 12
    • 9
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PERK Antikörper ist unkonjugiert
    Applikation
    • 75
    • 53
    • 40
    • 28
    • 26
    • 26
    • 13
    • 9
    • 8
    • 6
    • 6
    • 4
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Aufreinigung
    Purified
    Immunogen
    A portion of amino acids 148-175 from the human protein was used as the immunogen for this PERK antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product EIF2AK3 Primärantikörper
  • Applikationshinweise
    Titration of the PERK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the PERK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    Andere Bezeichnung
    PERK (EIF2AK3 Produkte)
    Synonyme
    EIF2AK3 antikoerper, AI427929 antikoerper, Pek antikoerper, Perk antikoerper, PEK antikoerper, PERK antikoerper, WRS antikoerper, eukaryotic translation initiation factor 2 alpha kinase 3 antikoerper, EIF2AK3 antikoerper, Eif2ak3 antikoerper
    Hintergrund
    PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It likely serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction Expression of this Type I membrane protein is ubiquitous, with highest levels seen in secretory tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
    UniProt
    Q9NZJ5
    Pathways
    Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
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