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PTEN Antikörper (pTyr336)
PTEN
Reaktivität: Human
DB, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN3032212
Produktdetails anti-PTEN Antikörper
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Target
Alle PTEN Antikörper anzeigen
PTEN
(Phosphatase and Tensin Homolog (PTEN))
Bindungsspezifität
Alle Epitope für PTEN Antikörper
pTyr336
Reaktivität
Alle Reaktivitäten für PTEN Antikörper
Human
Wirt
Alle Wirte für PTEN Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PTEN Antikörper
Polyklonal
Konjugat
Alle Konjugate für PTEN Antikörper
Dieser PTEN Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PTEN Antikörper
Dot Blot (DB), ELISA
Kreuzreaktivität (Details)
Expected species reactivity: Mouse
Aufreinigung
Antigen affinity purified
Immunogen
This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY336 of human PTEN.
Isotyp
Ig Fraction
Top Product
Discover our top product PTEN Primärantikörper
Alternativen
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anti-Phosphatase and Tensin Homolog (PTEN) (C-Term), (pSer380), (pThr382), (pThr383) antibody
PTEN
Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio)
WB, IHC, IF, IP, IC
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Applikationshinweise
Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
In 1X PBS pH 7.4 with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Details zu PTEN
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Target
PTEN
(Phosphatase and Tensin Homolog (PTEN))
Andere Bezeichnung
PTEN (PTEN Produkte )
Synonyme
10q23del antikoerper, BZS antikoerper, CWS1 antikoerper, DEC antikoerper, GLM2 antikoerper, MHAM antikoerper, MMAC1 antikoerper, PTEN1 antikoerper, TEP1 antikoerper, 2310035O07Rik antikoerper, A130070J02Rik antikoerper, AI463227 antikoerper, B430203M17Rik antikoerper, Mmac antikoerper, PTENP1 antikoerper, wu:fc52g04 antikoerper, zgc:73086 antikoerper, fa11a08 antikoerper, fb73f10 antikoerper, fc83f12 antikoerper, fd16b10 antikoerper, fk90e11 antikoerper, pten antikoerper, si:bz1g13.4 antikoerper, wu:fa11a08 antikoerper, wu:fb73f10 antikoerper, wu:fc83f12 antikoerper, wu:fd16b10 antikoerper, wu:fk90e11 antikoerper, phosphatase and tensin homolog antikoerper, phosphatase and tensin homolog L homeolog antikoerper, phosphatase and tensin homolog A antikoerper, phosphatase and tensin homolog B antikoerper, PTEN antikoerper, Pten antikoerper, pten.L antikoerper, ptena antikoerper, ptenb antikoerper
Hintergrund
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
UniProt
P60484
Pathways
T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Inositol Metabolic Process , Synaptic Membrane , Regulation of Cell Size , Autophagie , Platelet-derived growth Factor Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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