ROR2 Antikörper (AA 19-50)

Produktnummer ABIN3032442

Produktdetails anti-ROR2 Antikörper

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Bindungsspezifität: AA 19-50

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Aufreinigung: Purified

Immunogen: A portion of amino acids 19-50 from the human protein was used as the immunogen for this ROR2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the ROR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ROR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Andere Bezeichnung: ROR2 (ROR2 Produkte)

Synonyme: BDB antikoerper, BDB1 antikoerper, NTRKR2 antikoerper, Ntrkr2 antikoerper, mRor2 antikoerper, ROR2 antikoerper, bdb antikoerper, bdb1 antikoerper, Xror2 antikoerper, ntrkr2 antikoerper, MGC97773 antikoerper, LOC100219935 antikoerper, ror2 antikoerper, xror2 antikoerper, receptor tyrosine kinase like orphan receptor 2 antikoerper, receptor tyrosine kinase-like orphan receptor 2 antikoerper, receptor tyrosine kinase like orphan receptor 2 L homeolog antikoerper, ROR2 antikoerper, Ror2 antikoerper, ror2 antikoerper, ror2.L antikoerper

Hintergrund: ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.

UniProt: Q01974

Pathways: RTK Signalweg, WNT Signalweg