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SLUG Antikörper (AA 1-30)

SNAI2 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032603
  • Target Alle SLUG (SNAI2) Antikörper anzeigen
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Bindungsspezifität
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reaktivität
    • 49
    • 18
    • 13
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 37
    • 12
    Kaninchen
    Klonalität
    • 38
    • 10
    Polyklonal
    Konjugat
    • 31
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser SLUG Antikörper ist unkonjugiert
    Applikation
    • 25
    • 18
    • 12
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Kreuzreaktivität (Details)
    Expected species reactivity: Bovine, Mouse, Rat
    Aufreinigung
    Purified
    Immunogen
    A portion of amino acids 1-30 from the human protein was used as the immunogen for this SLUG antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SNAI2 Primärantikörper
  • Applikationshinweise
    Titration of the SLUG antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the SLUG antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Andere Bezeichnung
    SLUG (SNAI2) (SNAI2 Produkte)
    Synonyme
    Slug antikoerper, Slugh antikoerper, Snail2 antikoerper, snail family transcriptional repressor 2 antikoerper, snail family zinc finger 2 antikoerper, Snai2 antikoerper
    Hintergrund
    SNAI2/SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and  HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
    UniProt
    O43623
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