SOCS4 Antikörper (AA 227-254)

Produktnummer ABIN3029046

Produktdetails anti-SOCS4 Antikörper

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Bindungsspezifität: AA 227-254

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 227-254 from the human protein was used as the immunogen for this SOCS4 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the SOCS4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SOCS4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Andere Bezeichnung: SOCS4 (SOCS4 Produkte)

Hintergrund: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. [UniProt]

UniProt: Q8WXH5

Pathways: JAK-STAT Signalweg, EGFR Signaling Pathway