SOCS7 Antikörper (AA 458-486)

Produktnummer ABIN3029049

Produktdetails anti-SOCS7 Antikörper

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Bindungsspezifität: AA 458-486

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS7 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität (Details): Expected species reactivity: Mouse

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 458-486 from the human protein was used as the immunogen for this SOCS7 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the SOCS7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SOCS7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Andere Bezeichnung: SOCS7 (SOCS7 Produkte)

Hintergrund: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

UniProt: O14512