TFE3 Antikörper (AA 489-516)

Produktnummer ABIN3029201

Produktdetails anti-TFE3 Antikörper

Target: TFE3 (Transcription Factor E3 (TFE3))

Bindungsspezifität: AA 489-516

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TFE3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): Expected species reactivity: Bovine

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 489-516 from the human protein was used as the immunogen for this TFE3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the TFE3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TFE3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Andere Bezeichnung: TFE3 (TFE3 Produkte)

Synonyme: RCCP2 antikoerper, RCCX1 antikoerper, TFEA antikoerper, bHLHe33 antikoerper, F830016E06Rik antikoerper, Tcfe3 antikoerper, Tfe-3 antikoerper, RGD1559642 antikoerper, cb873 antikoerper, zgc:109815 antikoerper, transcription factor binding to IGHM enhancer 3 antikoerper, transcription factor E3 antikoerper, transcription factor binding to IGHM enhancer 3 S homeolog antikoerper, transcription factor binding to IGHM enhancer 3a antikoerper, TFE3 antikoerper, Tfe3 antikoerper, tfe3.S antikoerper, tfe3a antikoerper

Hintergrund: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

UniProt: P19532