TLK2 Antikörper (AA 141-171)
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- Target Alle TLK2 Antikörper anzeigen
- TLK2 (Tousled-Like Kinase 2 (TLK2))
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Bindungsspezifität
- AA 141-171
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TLK2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Purified
- Immunogen
- A portion of amino acids 141-171 from the human protein was used as the immunogen for this TLK2 antibody.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product TLK2 Primärantikörper
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- Applikationshinweise
- Titration of the TLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot the TLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- TLK2 (Tousled-Like Kinase 2 (TLK2))
- Andere Bezeichnung
- TLK2 (TLK2 Produkte)
- Synonyme
- tlk2 antikoerper, MGC149057 antikoerper, HsHPK antikoerper, PKU-ALPHA antikoerper, wu:fi16h09 antikoerper, wu:fi30g12 antikoerper, zgc:136697 antikoerper, 4933403M19Rik antikoerper, PKUalpha antikoerper, Tlk antikoerper, tousled like kinase 2 antikoerper, tousled-like kinase 2 antikoerper, tousled-like kinase 2 (Arabidopsis) antikoerper, tlk2 antikoerper, TLK2 antikoerper, Tlk2 antikoerper
- Hintergrund
- TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
- UniProt
- Q86UE8
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