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Ubiquilin 1 Antikörper (AA 40-70)

UBQLN1 Reaktivität: Human, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3029414
  • Target Alle Ubiquilin 1 (UBQLN1) Antikörper anzeigen
    Ubiquilin 1 (UBQLN1)
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-70
    Reaktivität
    • 55
    • 26
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 48
    • 6
    • 2
    Kaninchen
    Klonalität
    • 51
    • 5
    Polyklonal
    Konjugat
    • 31
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Ubiquilin 1 Antikörper ist unkonjugiert
    Applikation
    • 45
    • 34
    • 21
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Kreuzreaktivität (Details)
    Expected species reactivity: Rat
    Aufreinigung
    Purified
    Immunogen
    A portion of amino acids 40-70 from the human protein was used as the immunogen for this Ubiquilin1 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product UBQLN1 Primärantikörper
  • Applikationshinweise
    Titration of the Ubiquilin1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the Ubiquilin1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Ubiquilin 1 (UBQLN1)
    Andere Bezeichnung
    Ubiquilin1 (UBQLN1 Produkte)
    Synonyme
    UBQLN1 antikoerper, DA41 antikoerper, DSK2 antikoerper, PLIC-1 antikoerper, UBQN antikoerper, XDRP1 antikoerper, 1110046H03Rik antikoerper, 1810030E05Rik antikoerper, AU019746 antikoerper, C77538 antikoerper, D13Ertd372e antikoerper, Da41 antikoerper, Dsk2 antikoerper, Plic-1 antikoerper, Plic1 antikoerper, Xdrp1 antikoerper, ubiquilin 1 antikoerper, UBQLN1 antikoerper, Ubqln1 antikoerper
    Hintergrund
    Ubiquilin 1 (UBQLN1), also known as DA41, was isolated from an adult rat lung cDNA library, and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes. The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN. Human DA41 encodes a 589-amino acid protein with 86 % amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner. PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein. PLIC1, also called UBQLN1, shares 72 % amino acid identity with PLIC2,3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain. Unlike ubiquitin, the UBL domain of the PLICs does not have a diglycine motif in its C terminus. The UBA domain is present in multiple enzyme classes of the ubiquitination machinery. Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes. Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates, p53 and I-kappa-B-alpha (NFKBIA), but not a ubiquitin-independent substrate. PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The DA41 gene maps to chromosome 9q21.2-q21.3, a position overlapping a candidate tumor suppressor locus for bladder cancer.2
    UniProt
    Q9UMX0
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