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ADRBK2 Antikörper
ADRBK2
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-ADRBK2 Antikörper
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Target
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ADRBK2
(Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))
Reaktivität
Alle Reaktivitäten für ADRBK2 Antikörper
Human, Maus, Ratte
Wirt
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Kaninchen
Klonalität
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Polyklonal
Konjugat
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Dieser ADRBK2 Antikörper ist unkonjugiert
Applikation
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Western Blotting (WB)
Spezifität
This antibody detects endogenous levels of GRK 3 protein. (region surrounding Phe391)
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu ADRBK2
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Target
ADRBK2
(Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))
Andere Bezeichnung
beta-ARK-2 / ADRBK2 (ADRBK2 Produkte )
Synonyme
bark2 antikoerper, grk3 antikoerper, 4833444A01Rik antikoerper, AI851927 antikoerper, AW551196 antikoerper, Adrbk-2 antikoerper, Bark-2 antikoerper, GRK3 antikoerper, BARK2 antikoerper, Grk3 antikoerper, si:dz221d18.1 antikoerper, G protein-coupled receptor kinase 3 antikoerper, GRK3 antikoerper, grk3 antikoerper, Grk3 antikoerper
Hintergrund
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second essenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1, two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7.Synonyms: BARK2, Beta-adrenergic receptor kinase 2, G-protein-coupled receptor kinase 3, GRK3
Molekulargewicht
approx. 80 kDa
Gen-ID
157
NCBI Accession
NP_005151
UniProt
P35626
Pathways
Regulation of G-Protein Coupled Receptor Protein Signaling , Thromboxane A2 Receptor Signaling
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