MED17 Antikörper
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- Target Alle MED17 Antikörper anzeigen
- MED17 (Mediator Complex Subunit 17 (MED17))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MED17 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of CRSP77 protein. (region surrounding Val171)
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - Aufreinigung
- Affinity chromatography
- Reinheit
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product MED17 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- MED17 (Mediator Complex Subunit 17 (MED17))
- Andere Bezeichnung
- MED17 (MED17 Produkte)
- Synonyme
- crsp6 antikoerper, CRSP6 antikoerper, CRSP77 antikoerper, DRIP80 antikoerper, TRAP80 antikoerper, 77kDa antikoerper, C330002H14Rik antikoerper, Crsp6 antikoerper, Trap80 antikoerper, mediator of RNA polymerase II transcription subunit 17 antikoerper, mediator complex subunit 17 antikoerper, mediator complex subunit 17 L homeolog antikoerper, AOR_1_2446154 antikoerper, VDBG_01663 antikoerper, med17 antikoerper, med17.L antikoerper, MED17 antikoerper, Med17 antikoerper
- Hintergrund
- In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase. These complexes include CRSP (for cofactor required for Sp1 activation), which is required, in conjunction with TAFIIs, for transcriptional activation by Sp1. CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits, each having an individual molecular mass ranging from 33 to 200 kDa. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex.Synonyms: ARC77, Activator-recruited cofactor 77 kDa component, CRSP complex subunit 6, CRSP6, Cofactor required for Sp1 transcriptional activation subunit 6, DRIP77, DRIP80, Mediator complex subunit 17, Mediator of RNA polymerase II transcription subunit 17, TRAP80, Thyroid hormone receptor-associated protein complex 80 kDa component, Transcriptional coactivator CRSP77, Vitamin D3 receptor-interacting protein complex 80 kDa component
- Molekulargewicht
- approx. 73 kDa
- Gen-ID
- 9440
- NCBI Accession
- NP_004259
- UniProt
- Q9NVC6
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
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