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Acetylcholinesterase Antikörper
AChE
Reaktivität: Human, Ratte, Maus
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Acetylcholinesterase Antikörper
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Target
Alle Acetylcholinesterase (AChE) Antikörper anzeigen
Acetylcholinesterase (AChE)
Reaktivität
Alle Reaktivitäten für Acetylcholinesterase Antikörper
Human, Ratte, Maus
Wirt
Alle Wirte für Acetylcholinesterase Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Acetylcholinesterase Antikörper
Polyklonal
Konjugat
Alle Konjugate für Acetylcholinesterase Antikörper
Dieser Acetylcholinesterase Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Acetylcholinesterase Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of AChE I protein. (region surrounding Lys585)
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu Acetylcholinesterase
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Target
Acetylcholinesterase (AChE)
Andere Bezeichnung
Acetylcholinesterase (AChE Produkte )
Synonyme
ACEE antikoerper, ARACHE antikoerper, N-ACHE antikoerper, YT antikoerper, Ache antikoerper, GB14873 antikoerper, zgc:92550 antikoerper, ACE antikoerper, Dsim\\GD20515 antikoerper, GD20515 antikoerper, dsim_GLEANR_4292 antikoerper, ache antikoerper, mE1a antikoerper, mE1b antikoerper, mE1c antikoerper, mE1c-long antikoerper, mE1d antikoerper, mE1d' antikoerper, mE1e antikoerper, arache antikoerper, n-ache antikoerper, acetylcholinesterase (Cartwright blood group) antikoerper, acetylcholinesterase 2 antikoerper, acetylcholinesterase antikoerper, Acetylcholine esterase antikoerper, acetylcholinesterase (Cartwright blood group) L homeolog antikoerper, collagen type I alpha 2 chain antikoerper, ACHE antikoerper, AChE-2 antikoerper, Ache antikoerper, ache antikoerper, Dsim\Ace antikoerper, ache.L antikoerper, COL1A2 antikoerper, ACE-1 antikoerper
Hintergrund
Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer's disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.Synonyms: AChE, Acetylcholine Esterase, Acetylcholine-Esterase
Molekulargewicht
approx. 70 kDa
Gen-ID
43
NCBI Accession
NP_000656
UniProt
P22303
Pathways
Skeletal Muscle Fiber Development
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