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PIK3R1 Antikörper (pTyr199, pTyr458)
PI3K p85a
Reaktivität: Human, Maus, Ratte
WB, IHC (p), IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-PIK3R1 Antikörper
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Target
Alle PIK3R1 (PI3K p85a) Antikörper anzeigen
PIK3R1 (PI3K p85a)
(Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
Bindungsspezifität
Alle Epitope für PIK3R1 Antikörper
pTyr199, pTyr458
Reaktivität
Alle Reaktivitäten für PIK3R1 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für PIK3R1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PIK3R1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für PIK3R1 Antikörper
Dieser PIK3R1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PIK3R1 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Spezifität
This antibody detects endogenous levels of p85a/p55 only when phosphorylated at Tyr467/Tyr199.
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse, Rat.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
Top Product
Discover our top product PI3K p85a Primärantikörper
Alternativen
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anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 501-600) antibody
PI3K p85a
Reaktivität: Human, Maus, Ratte, Kaninchen
WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu PIK3R1
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Target
PIK3R1 (PI3K p85a)
(Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
Andere Bezeichnung
PIK3R1 / GRB1 (PI3K p85a Produkte )
Synonyme
PI3CG antikoerper, PI3K antikoerper, PI3Kgamma antikoerper, PIK3 antikoerper, AGM7 antikoerper, GRB1 antikoerper, p85 antikoerper, p85-ALPHA antikoerper, PI3KA antikoerper, AA414921 antikoerper, C530050K14 antikoerper, p50alpha antikoerper, p55alpha antikoerper, p85alpha antikoerper, wu:fb65b05 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antikoerper, phosphoinositide-3-kinase regulatory subunit 1 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antikoerper, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antikoerper, PIK3CG antikoerper, PIK3R1 antikoerper, Pik3r1 antikoerper, Pik3cb antikoerper, pik3r1 antikoerper
Hintergrund
The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulinstimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.Synonyms: PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha
Molekulargewicht
approx. 55, 85 kDa
Gen-ID
5295
NCBI Accession
NP_852556
UniProt
P27986
Pathways
T-Zell Rezeptor Signalweg , Response to Growth Hormone Stimulus , Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development , Hepatitis C , Protein targeting to Nucleus , VEGF Signaling , BCR Signaling , Warburg Effekt
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