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Cofilin Antikörper (pSer3)
CFL1
Reaktivität: Human, Maus, Ratte
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Cofilin Antikörper
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Target
Alle Cofilin (CFL1) Antikörper anzeigen
Cofilin (CFL1)
(Cofilin 1 (CFL1))
Bindungsspezifität
Alle Epitope für Cofilin Antikörper
pSer3
Reaktivität
Alle Reaktivitäten für Cofilin Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für Cofilin Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Cofilin Antikörper
Polyklonal
Konjugat
Alle Konjugate für Cofilin Antikörper
Dieser Cofilin Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Cofilin Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of Cofilin protein only when phosphorylated at Ser3.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Discover our top product CFL1 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu Cofilin
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Target
Cofilin (CFL1)
(Cofilin 1 (CFL1))
Andere Bezeichnung
Cofilin-1 (CFL1 Produkte )
Synonyme
cfl1 antikoerper, xac1 antikoerper, xac2 antikoerper, cfl antikoerper, cb86 antikoerper, sb:cb86 antikoerper, zgc:56501 antikoerper, wu:fb18a04 antikoerper, wu:fk77b03 antikoerper, 12/8 antikoerper, ADF antikoerper, ADF/cofilin antikoerper, Adf antikoerper, CG4254 antikoerper, Cadf antikoerper, D-cof antikoerper, D61 antikoerper, Dmel\\CG4254 antikoerper, T8 antikoerper, Tsr antikoerper, cofilin antikoerper, cofilin/ADF antikoerper, cofilin/actin depolymerizing factor homolog antikoerper, l(2)03101 antikoerper, l(2)k03101 antikoerper, l(2)k05633 antikoerper, l(2)k13409 antikoerper, ntf antikoerper, CFL antikoerper, AA959946 antikoerper, Cof antikoerper, CFL1 antikoerper, cofilin 1 (non-muscle) L homeolog antikoerper, cofilin 1 (non-muscle) antikoerper, cofilin 1 (non-muscle), like antikoerper, cofilin 1 antikoerper, twinstar antikoerper, cofilin antikoerper, cofilin 1, non-muscle antikoerper, Contrafreeloading antikoerper, cfl1.L antikoerper, cfl1 antikoerper, cfl1l antikoerper, CFL1 antikoerper, tsr antikoerper, COF1 antikoerper, TSTA_042790 antikoerper, Cfl1 antikoerper, CFL antikoerper
Hintergrund
Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.Synonyms: 18 kDa phosphoprotein, CFL, CFL1, Cofilin non-muscle isoform, p18
Molekulargewicht
approx. 19 kDa
Gen-ID
1072
NCBI Accession
NP_005498
UniProt
P23528
Pathways
Regulation of Cell Size , Tube Formation , Protein targeting to Nucleus , CXCR4-mediated Signaling Events
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