NMDA 1 Receptor Antikörper (pSer896)

Produktnummer ABIN498858

Produktdetails anti-NMDA 1 Receptor Antikörper

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Bindungsspezifität: pSer896

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMDA 1 Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of p-NMDAR1 protein. (region surrounding Ser896)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu NMDA 1 Receptor

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Andere Bezeichnung: NMDA Receptor 1 (NMDA R1 Produkte)

Synonyme: CG2902 antikoerper, DMNMDAR1 antikoerper, DNMDAR-I antikoerper, DNmdar antikoerper, DmelNmdar1 antikoerper, Dmel\\CG2902 antikoerper, DrNR1 antikoerper, NMDA antikoerper, NMDA R1 antikoerper, NMDAR1 antikoerper, NMdar1 antikoerper, NR1 antikoerper, NRI antikoerper, Nmdar antikoerper, dNR1 antikoerper, dnmdar-I antikoerper, nmr antikoerper, NMDA receptor 1 antikoerper, Nmdar1 antikoerper

Hintergrund: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous sytem including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1

Molekulargewicht: approx. 120 kDa

Gen-ID: 2902

NCBI Accession: NP_000823

UniProt: Q05586