DOCK180 antikoerper, ced5 antikoerper, 9130006G06Rik antikoerper, AI854900 antikoerper, D630004B07Rik antikoerper, RGD1566072 antikoerper, dedicator of cytokinesis 1 antikoerper, dedicator of cytokinesis protein 1 antikoerper, dedicator of cyto-kinesis 1 antikoerper, DOCK1 antikoerper, Dock1 antikoerper, dock1 antikoerper, CpipJ_CPIJ002759 antikoerper
Hintergrund
The v-Crk oncogene product shares homologous amino acid sequences, designated Src homology region 2 (SH2) and SH3, with many molecules involved in signal transduction. The v-Crk cellular homolog, c-Crk, is a member of a newly emerging class of genes including Nck and GRB2/ASH which encode proteins that consist primarily of SH2 and SH3 domains. Two distinct human c-Crk cDNAs, designated Crk I and Crk II, have been identified and shown to represent alternative splice products of c-Crk. The major translational product of c-Crk I has been identified as a 28 kDa variably expressed protein, while c-Crk II encodes a widely expressed 40 kDa protein and a more variably expressed 42 kDa protein. The major c-Crk transforming activity appears associated with c-Crk I p28 expression. DOCK 180, a 180 kDa protein downstream of Crk, has been identified as a major Crk-associated protein. When DOCK 180 is recruited to the plasma membrane from a cytoplasmic reservoir, presumably by Crk, changes in cellular morphology and spindle formation occur, suggesting DOCK 180 to be a Crk effector molecule.Synonyms: 180 kDa protein downstream of CRK, Dedicator of cytokinesis protein 1