Anoctamin 5 Antikörper (C-Term)

Produktnummer ABIN499159

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Anoctamin 5 in WB und EIA. Er zeigt eine Reaktivität gegenüber Maus und Human.

Kurzübersicht für Anoctamin 5 Antikörper (C-Term) (ABIN499159)

Target: Anoctamin 5 (ANO5)

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Anoctamin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Anoctamin 5 Antikörper

Bindungsspezifität: AA 798-828, C-Term

Spezifität: Recognizes ANO5 (C-term).

Aufreinigung: Protein A Chromatography followed by peptide affinity purification

Immunogen: Synthetic peptide -KLH conjugated between 798~828 amino acids from the C-terminal region of Human ANO5. Genename: ANO5

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Anoctamin 5

Target: Anoctamin 5 (ANO5)

Andere Bezeichnung: ANO5

Hintergrund: ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel. Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD), also known as osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood, however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity.Synonyms: Anoctamin-5, GDD1, Gnathodiaphyseal dysplasia 1 protein, TMEM16E, Transmembrane 16E

Gen-ID: 203859

NCBI Accession: NP_001136121

UniProt: Q75V66