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TNIP3 Antikörper (C-Term)

TNIP3 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499187
  • Target Alle TNIP3 Antikörper anzeigen
    TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))
    Bindungsspezifität
    • 15
    • 8
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus
    Wirt
    • 33
    Kaninchen
    Klonalität
    • 33
    Polyklonal
    Konjugat
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNIP3 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 13
    • 13
    • 11
    • 7
    • 6
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reactcs to ABIN3 near the carboxy terminus.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.
    Isotyp
    IgG
    Top Product
    Discover our top product TNIP3 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: ABIN3 antibody can be used for detection of ABIN3 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))
    Andere Bezeichnung
    TNIP3 (TNIP3 Produkte)
    Synonyme
    ABIN-3 antikoerper, LIND antikoerper, 9030611K07Rik antikoerper, TNIP3 antikoerper, TNFAIP3 interacting protein 3 antikoerper, TNIP3 antikoerper, Tnip3 antikoerper
    Hintergrund
    The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.Synonyms: A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN3, LIND, Listeria-induced gene protein, TNFAIP3-interacting protein 3
    Gen-ID
    79931
    NCBI Accession
    NP_079149
    UniProt
    Q96KP6
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
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