BCAS2 Antikörper (C-Term)

Produktnummer ABIN499423

Produktdetails anti-BCAS2 Antikörper

Target: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: BCAS2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BCAS2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BCAS2 antibody can be used for detection of BCAS2 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu BCAS2

Target: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Andere Bezeichnung: BCAS2 / DAM1 (BCAS2 Produkte)

Synonyme: DAM1 antikoerper, SPF27 antikoerper, Snt309 antikoerper, 6430539P16Rik antikoerper, AI132645 antikoerper, C76366 antikoerper, C80030 antikoerper, BCAS2 antikoerper, cb302 antikoerper, zgc:101730 antikoerper, BCAS2, pre-mRNA processing factor antikoerper, breast carcinoma amplified sequence 2 antikoerper, breast carcinoma amplified sequence 2 L homeolog antikoerper, BCAS2 antikoerper, Bcas2 antikoerper, bcas2 antikoerper, bcas2.L antikoerper, CpipJ_CPIJ003889 antikoerper

Hintergrund: BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.Synonyms: Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Pre-mRNA-splicing factor SPF27, SPF27

Gen-ID: 10286

UniProt: O75934