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BCL2L13 Antikörper (Intermediate Domain)

BCL2L13 Reaktivität: Human, Maus, Ratte WB, EIA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499433
  • Target Alle BCL2L13 Antikörper anzeigen
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Bindungsspezifität
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 17
    • 4
    Kaninchen
    Klonalität
    • 17
    • 4
    Polyklonal
    Konjugat
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BCL2L13 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide
    Isotyp
    IgG
    Top Product
    Discover our top product BCL2L13 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Abstract
    BCL2L13 Produkte
    Synonyme
    si:ch211-238n5.7 antikoerper, Mil1 antikoerper, BCL-RAMBO antikoerper, Bcl2-L-13 antikoerper, MIL1 antikoerper, E430016C20Rik antikoerper, Mil-1 antikoerper, BCL2 like 13 antikoerper, BCL2-like 13 (apoptosis facilitator) antikoerper, BCL2L13 antikoerper, bcl2l13 antikoerper, Bcl2l13 antikoerper
    Hintergrund
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1
    Gen-ID
    23786
    UniProt
    Q9BXK5
    Pathways
    Positive Regulation of Endopeptidase Activity
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