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BMF Antikörper (N-Term)

BMF Reaktivität: Human, Maus WB, EIA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499481
  • Target Alle BMF Antikörper anzeigen
    BMF (Bcl2 Modifying Factor (BMF))
    Bindungsspezifität
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 32
    • 13
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 27
    • 3
    • 3
    Kaninchen
    Klonalität
    • 27
    • 6
    Polyklonal
    Konjugat
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BMF Antikörper ist unkonjugiert
    Applikation
    • 25
    • 14
    • 11
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
    Spezifität
    EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human Bmf (N-Terminus) Peptide
    Isotyp
    IgG
    Top Product
    Discover our top product BMF Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: Bmf antibody can be used for detection of Bmf at 2 μg/mL. HepG2 or 293 celllysate can be used as a positive control and a band at approximately 25 kDa can bedetected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    BMF (Bcl2 Modifying Factor (BMF))
    Andere Bezeichnung
    BMF (BMF Produkte)
    Synonyme
    BMF antikoerper, AW260063 antikoerper, AW411872 antikoerper, Bcl2 modifying factor antikoerper, Bcl2 modifying factor L homeolog antikoerper, BCL2 modifying factor antikoerper, BMF antikoerper, bmf.L antikoerper, Bmf antikoerper
    Hintergrund
    Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1,2). Bmf is constitutively expressed in many tissues (1,2).Synonyms: Bcl-2-modifying factor
    Gen-ID
    90427
    NCBI Accession
    NP_277038
    UniProt
    Q96LC9
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