CARD8
Reaktivität: Human
WB, IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
AbBy Fluor® 680
Applikationshinweise
ELISA. Immunocytochemistry. Western Blot: CARD8 antibody can be used for detection of CARD8 at 2 μg/mL. K562 cell lysate can be used as Positive Control and a band at approximately 45 kDa canbe detected. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL
Buffer
PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C.
Target
CARD8
(Caspase Recruitment Domain Family, Member 8 (CARD8))
CARD8 antikoerper, CARDINAL antikoerper, DACAR antikoerper, DAKAR antikoerper, NDPP antikoerper, NDPP1 antikoerper, TUCAN antikoerper, caspase recruitment domain family, member 8 antikoerper, caspase recruitment domain-containing protein 8 antikoerper, caspase recruitment domain family member 8 antikoerper, CARD8 antikoerper, LOC718594 antikoerper
Hintergrund
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis (1,2), and caspase-1 and its related proteins ICEBERG and pesudo-ICE (3). Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein (2,4), it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappaB activation.Synonyms: Apoptotic protein NDPP-1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, Caspase recruitment domain-containing protein 8, DACAR, KIAA0955, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9