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CCDC98 Antikörper (N-Term)

FAM175A Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499595
  • Target Alle CCDC98 (FAM175A) Antikörper anzeigen
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    N-Term
    Reaktivität
    • 24
    • 18
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 36
    • 4
    Kaninchen
    Klonalität
    • 36
    • 4
    Polyklonal
    Konjugat
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CCDC98 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 13
    • 13
    • 13
    • 11
    • 8
    • 6
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to CCDC98.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Andere Bezeichnung
    CCDC98 (FAM175A Produkte)
    Synonyme
    CCDC98 antikoerper, abra1 antikoerper, ccdc98 antikoerper, fam175a antikoerper, ABRA1 antikoerper, 3830405G04Rik antikoerper, 5630400M01Rik antikoerper, AI506069 antikoerper, AL024423 antikoerper, AV118690 antikoerper, Ccdc98 antikoerper, RGD1305287 antikoerper, zgc:103522 antikoerper, abraxas 1, BRCA1 A complex subunit antikoerper, Coiled-coil domain-containing protein 98 antikoerper, BRCA1 A complex subunit antikoerper, family with sequence similarity 175 member A antikoerper, abraxas 2a, BRISC complex subunit antikoerper, abraxas 1, BRCA1 A complex subunit S homeolog antikoerper, ABRAXAS1 antikoerper, abraxas1 antikoerper, Abraxas1 antikoerper, FAM175A antikoerper, abraxas2a antikoerper, abraxas1.S antikoerper
    Hintergrund
    CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A
    Gen-ID
    84142
    NCBI Accession
    NP_620775
    UniProt
    Q6UWZ7
    Pathways
    DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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