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DARC Antikörper (C-Term)

DARC Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499710
  • Target Alle DARC Antikörper anzeigen
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Bindungsspezifität
    • 13
    • 12
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 30
    • 8
    • 2
    • 2
    Kaninchen
    Klonalität
    • 35
    • 6
    • 1
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 4
    • 3
    • 3
    Dieser DARC Antikörper ist unkonjugiert
    Applikation
    • 28
    • 25
    • 9
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to DARC.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.
    Isotyp
    IgG
    Top Product
    Discover our top product DARC Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Andere Bezeichnung
    CD234 / DARC (DARC Produkte)
    Synonyme
    DARC antikoerper, FY antikoerper, ACKR1 antikoerper, CCBP1 antikoerper, CD234 antikoerper, Dfy antikoerper, GPD antikoerper, GpFy antikoerper, WBCQ1 antikoerper, AA162249 antikoerper, Ackr1 antikoerper, ESTM35 antikoerper, Duffy blood group, chemokine receptor antikoerper, atypical chemokine receptor 1 (Duffy blood group) antikoerper, atypical chemokine receptor 1 antikoerper, DARC antikoerper, ACKR1 antikoerper, Ackr1 antikoerper
    Hintergrund
    DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.Synonyms: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor
    Gen-ID
    2532
    UniProt
    Q16570
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