FAF1 Antikörper (C-Term)

Produktnummer ABIN499818

Produktdetails anti-FAF1 Antikörper

Target: FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to FAF1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: FAF1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAF1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu FAF1

Target: FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

Andere Bezeichnung: FAF1 (FAF1 Produkte)

Synonyme: faf1 antikoerper, MGC53741 antikoerper, MGC80303 antikoerper, FAF1 antikoerper, zgc:55752 antikoerper, wu:fc25h12 antikoerper, HFAF1s antikoerper, UBXD12 antikoerper, UBXN3A antikoerper, hFAF1 antikoerper, AA408698 antikoerper, Dffrx antikoerper, Fam antikoerper, Fas (TNFRSF6) associated factor 1 S homeolog antikoerper, Fas (TNFRSF6) associated factor 1 L homeolog antikoerper, Fas associated factor 1 antikoerper, Fas (TNFRSF6) associated factor 1 antikoerper, Fas-associated factor 1 antikoerper, faf1.S antikoerper, faf1.L antikoerper, FAF1 antikoerper, faf1 antikoerper, Faf1 antikoerper

Hintergrund: Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis (1). FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain (1,2). Overexpression of FAF1 also decreases the basal level of NF-kappaB activity in transfected 293 cells, inhibits NF-kappaB activity induced by TNF-alpha, IL-1beta and lipopolysaccharide, and prevents NF-kappaB translocation to the nucleus (3), suggesting that another role of FAF1 is to negatively regulate the activity of NF-kappaB. FAF1 can also interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway (4). Multiple differentially spliced isoforms of FAF1 are known to exist.Synonyms: CGI-03, FAS-associated factor 1, UBX domain-containing protein 12, UBX domain-containing protein 3A, UBXD12, UBXN3A

Gen-ID: 11124

NCBI Accession: NP_008982

UniProt: Q9UNN5

Pathways: Maintenance of Protein Location