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GPR3 Antikörper (C-Term)

GPR3 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499914
  • Target Alle GPR3 Antikörper anzeigen
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Bindungsspezifität
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 30
    • 16
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 28
    • 4
    • 1
    Kaninchen
    Klonalität
    • 31
    • 2
    Polyklonal
    Konjugat
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GPR3 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 13
    • 10
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to GPR3.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    GPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.
    Isotyp
    IgG
    Top Product
    Discover our top product GPR3 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Andere Bezeichnung
    GPR3 / ACCA (GPR3 Produkte)
    Synonyme
    GPR3 antikoerper, ACCA antikoerper, Gpcr3 antikoerper, Gpcr20 antikoerper, Gpcr21 antikoerper, G protein-coupled receptor 3 antikoerper, G-protein coupled receptor 3 antikoerper, GPR3 antikoerper, Gpr3 antikoerper
    Hintergrund
    GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3
    Gen-ID
    2827
    UniProt
    P46089
    Pathways
    cAMP Metabolic Process
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