HAAO Antikörper (N-Term)

Produktnummer ABIN499940

Produktdetails anti-HAAO Antikörper

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAAO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Andere Bezeichnung: HAAO (HAAO Produkte)

Synonyme: Afu2g17450 antikoerper, 0610007K21Rik antikoerper, 0610012J07Rik antikoerper, 3-HAO antikoerper, 3-HAOxase antikoerper, 3HAO antikoerper, zgc:103585 antikoerper, HAO antikoerper, 3-hydroxyanthranilate 3,4-dioxygenase antikoerper, 3-hydroxyanthranilate 3,4-dioxygenase L homeolog antikoerper, SPO1774 antikoerper, CNB05620 antikoerper, AFUA_2G17450 antikoerper, Bcep18194_C7641 antikoerper, Kfla_5491 antikoerper, Micau_4935 antikoerper, RBRH_03005 antikoerper, Krodi_1278 antikoerper, haao antikoerper, HAAO antikoerper, Haao antikoerper, haao.L antikoerper

Hintergrund: HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.Synonyms: 3-HAO, 3-hydroxyanthranilate 3, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 4-dioxygenase, HAD

Gen-ID: 23498

NCBI Accession: NP_036337

UniProt: P46952