IRF8 Antikörper
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- Target Alle IRF8 Antikörper anzeigen
- IRF8 (Interferon Regulatory Factor 8 (IRF8))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IRF8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Spezifität
- IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.
- Aufreinigung
- Affinity chromatography purified via peptide column
- Immunogen
- Human IRF8 Peptide
- Isotyp
- IgG
- Top Product
- Discover our top product IRF8 Primärantikörper
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- Applikationshinweise
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ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C.
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- Target
- IRF8 (Interferon Regulatory Factor 8 (IRF8))
- Andere Bezeichnung
- IRF8 / ICSBP1 (IRF8 Produkte)
- Synonyme
- zgc:92252 antikoerper, IRF8 antikoerper, MGC140338 antikoerper, DKFZp469B0320 antikoerper, H-ICSBP antikoerper, ICSBP antikoerper, ICSBP1 antikoerper, IRF-8 antikoerper, icsbp1 antikoerper, AI893568 antikoerper, Icsbp1 antikoerper, Myls antikoerper, interferon regulatory factor 8 antikoerper, interferon regulatory factor 8 L homeolog antikoerper, irf8 antikoerper, IRF8 antikoerper, irf8.L antikoerper, Irf8 antikoerper
- Hintergrund
- Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases (2,3), but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells (4,5). Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia (6).Synonyms: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8
- Gen-ID
- 3394
- NCBI Accession
- NP_002154
- UniProt
- Q02556
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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