DEDD2 Antikörper (AA 201-300) (AbBy Fluor® 680)
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- Target Alle DEDD2 Antikörper anzeigen
- DEDD2 (Death Effector Domain Containing 2 (DEDD2))
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Bindungsspezifität
- AA 201-300
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DEDD2 Antikörper ist konjugiert mit AbBy Fluor® 680
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DEDD2
- Isotyp
- IgG
- Top Product
- Discover our top product DEDD2 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- DEDD2 (Death Effector Domain Containing 2 (DEDD2))
- Andere Bezeichnung
- DEDD2 (DEDD2 Produkte)
- Synonyme
- FLAME-3 antikoerper, MGC145883 antikoerper, 2410050E11Rik antikoerper, DEDD2 antikoerper, death effector domain containing 2 antikoerper, death effector domain containing 2 L homeolog antikoerper, death effector domain-containing DNA binding protein 2 antikoerper, DEDD2 antikoerper, dedd2.L antikoerper, dedd2 antikoerper, Dedd2 antikoerper
- Hintergrund
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Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,
Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
- Gen-ID
- 162989
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