Retinoic Acid Induced 12 (RAI12) Antikörper (AbBy Fluor® 680)
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- Target Alle Retinoic Acid Induced 12 (RAI12) Antikörper anzeigen
- Retinoic Acid Induced 12 (RAI12)
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- AbBy Fluor® 680
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DERP6/C17orf81
- Isotyp
- IgG
- Top Product
- Discover our top product RAI12 Primärantikörper
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- Applikationshinweise
- IF(IHC-P) 1:50-200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Retinoic Acid Induced 12 (RAI12)
- Andere Bezeichnung
- DERP6 (RAI12 Produkte)
- Synonyme
- C17orf81 antikoerper, DERP6 antikoerper, MST071 antikoerper, MSTP071 antikoerper, Derp6 antikoerper, Rai12 antikoerper, derp6 antikoerper, rai12 antikoerper, zgc:158278 antikoerper, zgc:158285 antikoerper, elongator acetyltransferase complex subunit 5 antikoerper, ELP5 antikoerper, Elp5 antikoerper, elp5 antikoerper
- Hintergrund
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Synonyms: MST071, MSTP071, chromosome 17 open reading frame 81, Dermal papilla derived protein 6, dermal papilla-derived protein 6, DERP6, HSPC002, S phase 2 protein, ELP5_HUMAN.
Background: DERP6, is a 316 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in liver, heart, testis, brain and skeletal muscle, DERP6 is thought to be involved in p53-mediated transcriptional regulation. The gene encoding DERP6 maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
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