C79673 antikoerper, Kindlin3 antikoerper, RGD1310168 antikoerper, MGC69069 antikoerper, MGC88900 antikoerper, KIND3 antikoerper, MIG-2 antikoerper, MIG2B antikoerper, UNC112C antikoerper, URP2 antikoerper, URP2SF antikoerper, zgc:64101 antikoerper, fermitin family member 3 antikoerper, fermitin family member 3 L homeolog antikoerper, fermitin family member 3b antikoerper, Fermt3 antikoerper, fermt3.L antikoerper, fermt3 antikoerper, FERMT3 antikoerper, fermt3b antikoerper
Hintergrund
The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.Synonyms: Fermitin family homolog 3, KIND3, Kindlin-3, MIG2-like protein, MIG2B, URP2, Unc-112-related protein 2