PAFAH1B1 Antikörper (C-Term)
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- Target Alle PAFAH1B1 Antikörper anzeigen
- PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PAFAH1B1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody detects PAFAH1B1 / LIS1.
- Aufreinigung
- Peptide affinity chromatography
- Immunogen
- LIS1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.
- Isotyp
- IgG
- Top Product
- Discover our top product PAFAH1B1 Primärantikörper
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- Applikationshinweise
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide as preservative
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C.
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- Target
- PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))
- Andere Bezeichnung
- PAFAH1B1 / LIS1 (PAFAH1B1 Produkte)
- Synonyme
- LIS1 antikoerper, LIS2 antikoerper, MDCR antikoerper, MDS antikoerper, PAFAH antikoerper, LIS-1 antikoerper, Lis1 antikoerper, MMS10-U antikoerper, Mdsh antikoerper, Ms10u antikoerper, Pafaha antikoerper, lis2 antikoerper, mdcr antikoerper, mds antikoerper, pafah antikoerper, pafah1b1-b antikoerper, PAFAHA antikoerper, Lis1a antikoerper, platelet activating factor acetylhydrolase 1b regulatory subunit 1 antikoerper, platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 antikoerper, platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b antikoerper, PAFAH1B1 antikoerper, Pafah1b1 antikoerper, pafah1b1.L antikoerper, pafah1b1a antikoerper, pafah1b1b antikoerper
- Hintergrund
- Lissencephaly is a severe brain developmental disease characterized by the mislocalization of cortical neurons, a smooth cerebral surface, mental retardation, and seizures. Classical lissencephaly is caused by sporadic mutations in the LIS1 gene. While LIS1 is known to act in a pathway deactivating the lipid messenger platelet-activating factor, LIS1 forms a complex with Nudel and 14-3-3e which is then transported from neuronal cell bodies through the actions of DISC1 and KIF5A, a microtubule-dependent directed motor protein kinesin. Decreased expression of LIS1 blocked neural stem cell division, morphogenesis, and motility, suggesting that LIS1 plays an important role in neuronal cell proliferation and localization in the developing brain. At least two isoforms of LIS1 are known to exist.Synonyms: LIS-1, Lissencephaly-1 protein, MDCR, MDS, PAF acetylhydrolase 45 kDa subunit, PAF-AH alpha, PAFAH alpha, PAFAHA, Platelet-activating factor acetylhydrolase IB subunit alpha
- Gen-ID
- 5048
- UniProt
- P43034
- Pathways
- M Phase, Regulation of Cell Size
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