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MADD Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-MADD-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, MADD in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN500216

Kurzübersicht für MADD Antikörper (C-Term) (ABIN500216)

Target

Alle MADD Antikörper anzeigen
MADD (MAP-Kinase Activating Death Domain (MADD))

Reaktivität

  • 32
  • 23
  • 16
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 39
Kaninchen

Klonalität

  • 38
  • 1
Polyklonal

Konjugat

  • 18
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MADD Antikörper ist unkonjugiert

Applikation

  • 15
  • 15
  • 13
  • 10
  • 7
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects MADD at C-term.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, mouse, rat

    Aufreinigung

    DEAE purified

    Immunogen

    MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western blot: 1: 250 - 1: 500 dilution, 200 to 220 kDa bands should be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target

    MADD (MAP-Kinase Activating Death Domain (MADD))

    Andere Bezeichnung

    MADD

    Hintergrund

    MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98 % identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94 % overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87 % identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.Synonyms: DENN, IG20, MAP kinase-activating death domain protein, RAB3GEP, Rab3 GDP/GTP exchange factor

    Gen-ID

    8567

    UniProt

    Q8WXG6

    Pathways

    Caspase Kaskade in der Apoptose
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