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MTBP Antikörper (Middle Region)

MTBP Reaktivität: Human WB, EIA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500294
  • Target Alle MTBP Antikörper anzeigen
    MTBP (MDM2 Binding Protein (MTBP))
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 122-139, Middle Region
    Reaktivität
    • 43
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 41
    • 2
    Kaninchen
    Klonalität
    • 41
    • 2
    Polyklonal
    Konjugat
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTBP Antikörper ist unkonjugiert
    Applikation
    • 32
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
    Spezifität
    This antibody detects MTBP at center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    MTBP antibody was raised against a synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids (7).
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MTBP (MDM2 Binding Protein (MTBP))
    Andere Bezeichnung
    MTBP (MTBP Produkte)
    Synonyme
    MDM2BP antikoerper, AI429604 antikoerper, MDM2 binding protein antikoerper, Mdm2, transformed 3T3 cell double minute p53 binding protein antikoerper, MTBP antikoerper, Mtbp antikoerper
    Hintergrund
    The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6) and MTBP (7), were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53 (7). MTBP is expressed in a variety of normal tissues (7).Synonyms: Mdm2, Mdm2-binding protein, hMTBP
    Gen-ID
    27085
    NCBI Accession
    NP_071328
    UniProt
    Q96DY7
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