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MYD88 Antikörper (C-Term)
MYD88
Reaktivität: Human, Maus, Ratte
WB, EIA
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-MYD88 Antikörper
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Target
Alle MYD88 Antikörper anzeigen
MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Bindungsspezifität
Alle Epitope für MYD88 Antikörper
AA 279-296, C-Term
Reaktivität
Alle Reaktivitäten für MYD88 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für MYD88 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MYD88 Antikörper
Polyklonal
Konjugat
Alle Konjugate für MYD88 Antikörper
Dieser MYD88 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MYD88 Antikörper
Western Blotting (WB), Enzyme Immunoassay (EIA)
Spezifität
This antibody detects MYD88 at C-term.
Kreuzreaktivität (Details)
Species reactivity (tested):Human, mouse, rat
Aufreinigung
Peptide affinity chromatography
Immunogen
MyD88 antibody was raised against a peptide corresponding to amino acids 279 to 296 of human MyD88, which are identical to those of mouse.
Isotyp
IgG
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Discover our top product MYD88 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
ELISA. Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Buffer
PBS containing 0.02 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Details zu MYD88
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Target
MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Andere Bezeichnung
MYD88 (MYD88 Produkte )
Synonyme
MYD88D antikoerper, XMyD88 antikoerper, myd88d antikoerper, MGC84928 antikoerper, CG2078 antikoerper, DMMYD88 antikoerper, DmMyD88 antikoerper, DmMyd88 antikoerper, Dmel\\CG2078 antikoerper, EP(2)2535 antikoerper, Kra antikoerper, LD20892 antikoerper, MYD88 antikoerper, MyD88 antikoerper, Myd88F antikoerper, dMyD88 antikoerper, dMyd88 antikoerper, kra antikoerper, myd88 antikoerper, zgc:103541 antikoerper, GB12344 antikoerper, NV10640 antikoerper, myd88-a antikoerper, myd88-b antikoerper, myeloid differentiation primary response 88 antikoerper, myeloid differentiation primary response 88 S homeolog antikoerper, myeloid differentiation primary response gene 88 antikoerper, CG2078 gene product from transcript CG2078-RB antikoerper, myeloid differentiation primary response protein MyD88-A antikoerper, myeloid differentiation primary response protein MyD88 antikoerper, myeloid differentiation factor 88 antikoerper, myeloid differentiation primary response 88 L homeolog antikoerper, MYD88 antikoerper, myd88.S antikoerper, Myd88 antikoerper, myd88 antikoerper, LOC413194 antikoerper, LOC100118553 antikoerper, LOC575153 antikoerper, myd88.L antikoerper
Hintergrund
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
Gen-ID
4615
UniProt
Q99836
Pathways
NF-kappaB Signalweg , TLR Signalweg , Neurotrophin Signalübertragung , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Toll-Like Receptors Cascades
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