GARNL1 Antikörper (AA 631-730) (AbBy Fluor® 750)
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- Target Alle GARNL1 (RALGAPA1) Antikörper anzeigen
- GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
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Bindungsspezifität
- AA 631-730
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GARNL1 Antikörper ist konjugiert mit AbBy Fluor® 750
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human GARNL1
- Isotyp
- IgG
- Top Product
- Discover our top product RALGAPA1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
- Andere Bezeichnung
- GARNL1 (RALGAPA1 Produkte)
- Synonyme
- GARNL1 antikoerper, GRIPE antikoerper, TULIP1 antikoerper, Garnl1 antikoerper, Tulip1 antikoerper, tulip1 antikoerper, tulip1.2 antikoerper, 2310003F20Rik antikoerper, 4930400K19Rik antikoerper, AI563624 antikoerper, mKIAA0884 antikoerper, p240 antikoerper, Ral GTPase activating protein catalytic alpha subunit 1 antikoerper, Ral GTPase activating protein, alpha subunit 1 (catalytic) antikoerper, Ral GTPase activating protein, alpha subunit 1 antikoerper, RALGAPA1 antikoerper, Ralgapa1 antikoerper, ralgapa1 antikoerper
- Hintergrund
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Synonyms: DKFZp566D133, DKFZp667F074, GAP related interacting partner to E12, GARN L1, GARNL 1, GRIPE, GTPase activating Rap/RanGAP domain like 1, KIAA0884, Tuberin like protein 1, TULIP 1. TULIP1, RGPA1_HUMAN.
Background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.
- Gen-ID
- 253959
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