Neurturin Antikörper (AA 178-193)
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- Target Alle Neurturin (NRTN) Antikörper anzeigen
- Neurturin (NRTN)
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Bindungsspezifität
- AA 178-193
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Neurturin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects Neurturin.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human
- Aufreinigung
- Peptide affinity chromatography
- Immunogen
- Neurturin antibody was raised against a peptide corresponding to amino acids 178 to 193 of human neurturin.
- Isotyp
- IgG
- Top Product
- Discover our top product NRTN Primärantikörper
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- Applikationshinweise
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ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- Neurturin (NRTN)
- Andere Bezeichnung
- Neurturin (NRTN Produkte)
- Synonyme
- NRTN antikoerper, NTN antikoerper, neurturin antikoerper, NRTN antikoerper, Nrtn antikoerper
- Hintergrund
- Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently (3-8) and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-Β-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. NTN binds to and forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.Synonyms: NRTN
- Gen-ID
- 4902
- NCBI Accession
- NP_004549
- UniProt
- Q99748
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