GUCY1A1 Antikörper (AA 301-400) (AbBy Fluor® 680)
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- Target Alle GUCY1A1 Antikörper anzeigen
- GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))
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Bindungsspezifität
- AA 301-400
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GUCY1A1 Antikörper ist konjugiert mit AbBy Fluor® 680
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 1
- Isotyp
- IgG
- Top Product
- Discover our top product GUCY1A1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))
- Andere Bezeichnung
- Guanylyl Cyclase alpha 1 (GUCY1A1 Produkte)
- Synonyme
- GC-SA3 antikoerper, GUC1A3 antikoerper, GUCA3 antikoerper, GUCSA3 antikoerper, GUCY1A1 antikoerper, 1200016O07Rik antikoerper, Gucy1a1 antikoerper, SGC antikoerper, im:7136149 antikoerper, sgc1a1 antikoerper, zgc:112159 antikoerper, gucy1a3 antikoerper, guanylate cyclase 1 soluble subunit alpha antikoerper, guanylate cyclase 1, soluble, alpha 3 antikoerper, guanylate cyclase 1 soluble subunit alpha 3 antikoerper, soluble guanylyl cyclase alpha subunit antikoerper, GUCY1A3 antikoerper, Gucy1a3 antikoerper, gucy1a3 antikoerper
- Hintergrund
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Synonyms: GUCA3, MYMY6, GC-SA3, GUC1A3, GUCSA3, GUCY1A1, Guanylate cyclase soluble subunit alpha-3, GCS-alpha-3, GCS-alpha-1, Soluble guanylate cyclase large subunit, GUCY1A3
Background: Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
- Gen-ID
- 2982
- UniProt
- Q02108
- Pathways
- Myometrial Relaxation and Contraction
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