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ORAI1 Antikörper (C-Term)

ORAI1 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500421
  • Target Alle ORAI1 Antikörper anzeigen
    ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))
    Bindungsspezifität
    • 11
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 61
    • 24
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 57
    • 6
    • 1
    Kaninchen
    Klonalität
    • 58
    • 6
    Polyklonal
    Konjugat
    • 29
    • 8
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ORAI1 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 38
    • 18
    • 9
    • 8
    • 8
    • 4
    • 4
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects ORAI1 at C-term. It is predicted to have no cross-reactivity to ORAI2 or ORAI3.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    ORAI1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))
    Andere Bezeichnung
    ORAI1 (ORAI1 Produkte)
    Synonyme
    CRACM1 antikoerper, ORAT1 antikoerper, TMEM142A antikoerper, RGD1311873 antikoerper, D730049H07Rik antikoerper, Tmem142a antikoerper, orai-1 antikoerper, im:7146264 antikoerper, orai1 antikoerper, tmem142a antikoerper, zgc:109721 antikoerper, orai2 antikoerper, ORAI1 antikoerper, LOC100218031 antikoerper, ORAI calcium release-activated calcium modulator 1 antikoerper, ORAI calcium release-activated calcium modulator 1b antikoerper, ORAI calcium release-activated calcium modulator 1 S homeolog antikoerper, ORAI1 antikoerper, Orai1 antikoerper, orai1b antikoerper, orai1.S antikoerper, orai1 antikoerper
    Hintergrund
    Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE.Synonyms: CRACM1, Calcium release-activated calcium channel protein 1, ORAI-1, Protein orai-1, TMEM142A, Transmembrane protein 142A
    Gen-ID
    84876
    UniProt
    Q96D31
    Pathways
    T-Zell Rezeptor Signalweg, BCR Signaling
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