TP53AIP1 Antikörper (N-Term)

Produktnummer ABIN500433

Produktdetails anti-TP53AIP1 Antikörper

Target: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53AIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Spezifität: This antibody dreacts to p53AIP1. It will detect all three isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Peptide affinity chromatograpy

Immunogen: p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 4 - 8 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-TP53AIP1 Antikörper (ABIN500433)

Ohno, Naito, Mukai, Yabuta, Nojima: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." in: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).

Details zu TP53AIP1

Target: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Andere Bezeichnung: TP53AIP1 (TP53AIP1 Produkte)

Synonyme: P53AIP1 antikoerper, tumor protein p53 regulated apoptosis inducing protein 1 antikoerper, TP53AIP1 antikoerper

Hintergrund: The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to existSynonyms: p53-regulated apoptosis-inducing protein 1, p53AIP1

Gen-ID: 63970

UniProt: Q9HCN2