TP53INP1 Antikörper (N-Term)

Produktnummer ABIN500435

Produktdetails anti-TP53INP1 Antikörper

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53INP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects TP53INP1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Peptide Affinity Chromatography

Immunogen: A synthetic peptide corresponding to 14 amino acids near the amino terminus of Human p53DINP1. .Remarks: This sequence is identical between apha and beta forms of the p53DINP1 proteins, and differs by one amino acid from those of Mouse.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot (1-2 μg/mL). Human lung tissue lysate can be used as a Positive Control and a band at 27 kDa can bedetected. A lower band at 18 kDa was detected in Human spleen, and Mouse liver andkidney tissue lysates, which may represent the p53DINP1-beta form. Immunohistochemistry on Paraffin Sections (2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Referenzen für anti-TP53INP1 Antikörper (ABIN500435)

Ferrajoli, Ivan, Ciccone, Shimizu, Kita, Ohtsuka, DAbundo, Qiang, Lerner, Nouraee, Rabe, Rassenti, Van Roosbroeck, Manning, Yuan, Zhang, Shanafelt, Wierda, Sabbioni, Tarrand, Estrov, Radovich, Liang et al.: "Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. ..." in: EBioMedicine, Vol. 2, Issue 6, pp. 572-82, (2016) (PubMed).

Details zu TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Andere Bezeichnung: TP53INP1 (TP53INP1 Produkte)

Synonyme: cb1036 antikoerper, wu:fb70a09 antikoerper, wu:fi13h08 antikoerper, zgc:158431 antikoerper, TP53INP1 antikoerper, 2700057G22Rik antikoerper, SIP antikoerper, SIP18 antikoerper, SIP27 antikoerper, Stinp antikoerper, Teap antikoerper, TP53DINP1 antikoerper, TP53INP1A antikoerper, TP53INP1B antikoerper, p53DINP1 antikoerper, Trp53inp1 antikoerper, tumor protein p53 inducible nuclear protein 1 antikoerper, tumor protein p53 inducible nuclear protein 1 S homeolog antikoerper, transformation related protein 53 inducible nuclear protein 1 antikoerper, TP53INP1 antikoerper, tp53inp1.S antikoerper, tp53inp1 antikoerper, Trp53inp1 antikoerper, Tp53inp1 antikoerper

Hintergrund: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2).?A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-a and p53DINP1-b or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).Synonyms: P53DINP1, SIP, Stress-induced protein, Tumor protein p53-inducible nuclear protein 1, p53-dependent damage-inducible nuclear protein 1, p53-inducible nuclear protein 1

Gen-ID: 94241

UniProt: Q96A56