PALB2 Antikörper (C-Term)

Produktnummer ABIN500447

Produktdetails anti-PALB2 Antikörper

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PALB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects PALB2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-PALB2 Antikörper (ABIN500447)

Loke, Pearlman, Upadhyay, Tesfa, Shao, Ostrer: "Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway." in: Human molecular genetics, Vol. 24, Issue 11, pp. 3030-7, (2016) (PubMed).

Details zu PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Andere Bezeichnung: PALB2 (PALB2 Produkte)

Hintergrund: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.Synonyms: FANCN, Partner and localizer of BRCA2

Gen-ID: 79728

UniProt: Q86YC2

Pathways: DNA Reparatur