Hippocalcin Antikörper (AA 101-193) (AbBy Fluor® 750)

Produktnummer ABIN5004648

Produktdetails anti-Hippocalcin Antikörper (AbBy Fluor® 750)

Target: Hippocalcin (HPCA)

Bindungsspezifität: AA 101-193

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hippocalcin Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hippocalcin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Hippocalcin

Target: Hippocalcin (HPCA)

Andere Bezeichnung: Hippocalcin (HPCA Produkte)

Synonyme: zgc:73126 antikoerper, MGC80408 antikoerper, MGC84992 antikoerper, bdr2 antikoerper, BDR2 antikoerper, hippocalcin antikoerper, hippocalcin S homeolog antikoerper, hpca antikoerper, hpca.S antikoerper, HPCA antikoerper, Hpca antikoerper

Hintergrund:

Synonyms: BDR 2, BDR2, Calcium binding protein BDR 2, Calcium binding protein BDR2, Calcium-binding protein BDR-2, Hpca, HPCA_HUMAN, Neuron specic calcium binding protein hippocalcin, Neuron specic calcium-binding protein hippocalcin, Neuron-specic calcium-binding protein hippocalcin,P23K.

Background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.