PRDM16 Antikörper (C-Term)

Produktnummer ABIN500533

Produktdetails anti-PRDM16 Antikörper

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Aufreinigung: Peptide Affinity Chromatography

Immunogen: PRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of Human PRDM16.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections. Positive Control: Rat Brain Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt store the antibody (in aliquots) at -20 °C.

Details zu PRDM16

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Andere Bezeichnung: PRDM16 (PRDM16 Produkte)

Synonyme: PRDM16 antikoerper, wu:fc09g08 antikoerper, MEL1 antikoerper, PFM13 antikoerper, 5730557K01Rik antikoerper, C130091E20 antikoerper, csp1 antikoerper, mKIAA1675 antikoerper, mel1 antikoerper, PR/SET domain 16 antikoerper, PR domain containing 16 antikoerper, PRDM16 antikoerper, prdm16 antikoerper, Prdm16 antikoerper

Hintergrund: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.Synonyms: KIAA1675, MDS1/EVI1-like gene 1, MEL1, PFM13, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1

Gen-ID: 63976

UniProt: Q9HAZ2

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation