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UIMC1 Antikörper (N-Term)

UIMC1 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500569
  • Target Alle UIMC1 Antikörper anzeigen
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Bindungsspezifität
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 31
    • 7
    • 5
    Human, Maus
    Wirt
    • 28
    • 2
    • 1
    Kaninchen
    Klonalität
    • 31
    Polyklonal
    Konjugat
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UIMC1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects UIMC1 / RAP80 at N-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    RAP80 antibody was raised against a 17 amino acid peptide from near the amino terminus of human RAP80.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA: Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Andere Bezeichnung
    UIMC1 / RAP80 (UIMC1 Produkte)
    Synonyme
    UIMC1 antikoerper, RAP80 antikoerper, X2HRIP110 antikoerper, 9430016E08Rik antikoerper, D330018D10Rik antikoerper, D630032M02Rik antikoerper, RIP110 antikoerper, Rxrip110 antikoerper, RGD1307009 antikoerper, ubiquitin interaction motif containing 1 antikoerper, UIMC1 antikoerper, Uimc1 antikoerper
    Hintergrund
    RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.Synonyms: BRCA1-A complex subunit RAP80, RXRIP110, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1
    Gen-ID
    51720
    UniProt
    Q96RL1
    Pathways
    DNA Reparatur, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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